Gestational growth trajectories derived from a dynamic fetal–placental scaling law
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Authors
Baller, Daniel
Thomas, Diana M.
Cummiskey, Kevin
Bredlau, Carl
Schwartz, Nadav
Orzechowski, Kelly
Miller, Richard C.
Odibo, Anthony
Shah, Ruchit
Salafia, Carolyn M.
Issue Date
2019
Type
journal-article
Language
Keywords
Differential equation , Logistic growth model , Nonlinear regression , Fetal growth curves , Placenta , Placenta volume
Alternative Title
Abstract
Fetal trajectories characterizing growth rates in utero have relied primarily on goodness of fit rather than mechanistic properties exhibited in utero. Here, we use a validated fetal–placental allometric scaling law and a first principles differential equations model of placental volume growth to generate biologically meaningful fetal–placental growth curves. The growth curves form the foundation for understanding healthy versus at-risk fetal growth and for identifying the timing of key events in utero.
Description
Citation
Baller et al., “Gestational Growth Trajectories Derived from a Dynamic Fetal–Placental Scaling Law.”
Publisher
Journal of The Royal Society Interface
License
Journal
Volume
Issue
PubMed ID
ISSN
1742-5689
1742-5662
1742-5662