Progress in the development of olfactory-based bioelectronic chemosensors

Cave, John W.; Wickiser, John K.; Mitropoulos, Alexander

Progress in the development of olfactory-based bioelectronic chemosensors

Date

2019

Authors

Cave, John W.

Wickiser, John K.

Mitropoulos, Alexander

Publisher

Biosensors and Bioelectronics

Abstract

Artificial chemosensory devices have a wide range of applications in industry, security, and medicine. The development of these devices has been inspired by the speed, sensitivity, and selectivity by which the olfactory system in animals can probe the chemical nature of the environment. In this review, we examine how molecular and cellular components of natural olfactory systems have been incorporated into artificial chemosensors, or bioelectronic sensors. We focus on the biological material that has been combined with signal transduction systems to develop artificial chemosensory devices. The strengths and limitations of different biological chemosensory material at the heart of these devices, as well as the reported overall effectiveness of the different bioelectronic sensor designs, is examined. This review also discusses future directions and challenges for continuing to advance development of bioelectronic sensors.

Keywords

Bioelectronic nose, Biosensor, Chemosensor, Odorant binding protein, Odorant receptor, Olfaction

Citation

Cave JW, Wickiser JK, Mitropoulos AN. Progress in the development of olfactory-based bioelectronic chemosensors. Biosens Bioelectron. 2019 Jan 1;123:211-222. doi: 10.1016/j.bios.2018.08.063. Epub 2018 Aug 27. PMID: 30201333.