Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective
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Authors
Kumar, Amrendra
Suryadevara, Naveenchandra
Hill, Timothy M.
Bezbradica, Jelena S.
Kaer, Luc Van
Joyce, Sebastian
Issue Date
2017
Type
journal-article
Language
Keywords
NKT Cells , Cancer Immunotherapy
Alternative Title
Abstract
Type I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells leads to rapid pro-inflammatory and immune modulatory cytokine and chemokine responses. This property of NKT cells, in conjunction with their interactions with antigen-presenting cells, controls downstream innate and adaptive immune responses against cancers and infectious diseases, as well as in several inflammatory disorders. NKT cell properties are acquired during development in the thymus and by interactions with the host microbial consortium in the gut, the nature of which can be influenced by NKT cells. This latter property, together with the role of the host microbiota in cancer therapy, necessitates a new perspective. Hence, this review provides an initial approach to understanding NKT cells from an ecological evolutionary developmental biology (eco-evo-devo) perspective.
Description
Citation
Kumar et al., "Natural Killer T Cells."
Publisher
Frontiers in Immunology
License
Journal
Volume
Issue
PubMed ID
ISSN
1664-3224